10,000x water solubility

Dose: 100mg/100mL
(Left) RenoCidin™ solution
(Right) Native hesperidin suspension

600% superior bioavailability

Journal of Agricultural and Food Chemistry 2021, 69(35)
doi: 10.1021/acs.jafc.1c04298

TOXOCITY STUDY

This study confirmed the oral toxicity and genotoxicity profile of standardized RenoCidin™ under good laboratory practice (GLP) conditions.

  • Acute oral toxicity study
  • Ames test
  • In vitro mammalian chromosomal aberration test
  • In vivo mammalian erythrocyte micronucleus test
  • Repeated dose 28-day oral toxicity study
precesion health benefits
SCI publication
clinical studies
scentific-based evidence
precesion health benefits
clinical studies
SCI publication
scentific-based evidence

♦ Exercise Performance

Randomized, double-blind, placebo-controlled human trial

Thirty-two healthy adults (18–40 years old) were evaluated for biomechanical and biochemical responses following exercise-induced muscle damage (EIMD). After supplementing with 100 mg of RenoCidin™ daily for 8 weeks, participants demonstrated improvements in muscle strength and explosive power, along with attenuated elevations in muscle-damage markers and favorable changes in stress-related hormone responses. These findings collectively suggest beneficial effects on exercise performance, endurance, and post-exercise recovery.

♦ Metabolic Health

Randomized, double-blind, placebo-controlled human trial

Thirty-two borderline-hyperlipidemic adults (18–40 years old; baseline TC ~200 mg/dL) were enrolled into placebo or RenoCidin™ groups to evaluate effects on blood lipid and glucose-related markers. Supplementing with 100 mg of RenoCidin™ for 8 weeks resulted in significant improvements in lipid-related metabolic indicators—including TC, TG, HDL, and LDL—relative to baseline and placebo.

♦ Circulation Health

[ Clinical trial ]
The study is ongoing (2025/12-2027/06)

[ In-house data ]
The objective of this study was to evaluate whether supplementation with 50 mg of RenoCidin™ promotes the recovery of skin temperature following cold-water loading. Cold water (15 °C) was applied to the subject’s hand for 5 minutes, after which skin temperature was monitored over time using a thermal imager to assess the rate of temperature recovery.

The results indicated that intake of RenoCidin™ significantly enhanced the recovery of skin temperature compared with the placebo.

♦ Cardiovascular Health

Food & Nutrition Research, 68.
DOI: https://doi.org/10.29219/fnr.v68.10682

RenoCidin™ showed no cytotoxicity to endothelial cells and exhibited trends consistent with improved vascular function.
The study in high-fat–diet mice further suggested that RenoCidin™ may support cardiovascular health by reducing inflammatory markers, attenuating weight gain, and modulating circulation-related parameters.

Relevant Peer-Reviewed Publications

HEALTHY AGEING

1.Yeh, C. H., Shen, Z. Q., Wang, T. W., Kao, C. H., Teng, Y. C., Yeh, T. K., … & Tsai, T. F. (2022). Hesperetin promotes longevity and delays aging via activation of Cisd2 in naturally aged mice. Journal of biomedical science, 29(1), 1-21. https://doi.org/10.1186/s12929-022-00838-7

2.Yeh, C. H., Shen, Z. Q., Lin, C. C., Lu, C. K., & Tsai, T. F. (2022). Rejuvenation: Turning Back Time by Enhancing CISD2. International Journal of Molecular Sciences, 23(22), 14014.https://doi.org/10.3390/ijms232214014

3.Luo, Y., Fan, H., Tan, X., & Li, Z. (2021). Hesperetin rescues emotional memory and synaptic plasticity deficit in aged rats. Behavioral Neuroscience, 135(6), 721. https://doi.org/10.1037/bne0000475

4.Miler, M., Živanović, J., Ajdžanović, V., Oreščanin-Dušić, Z., Milenković, D., Konić-Ristić, A., … & Šošić-Jurjević, B. (2016). Citrus flavanones naringenin and hesperetin improve antioxidant status and membrane lipid compositions in the liver of old-aged Wistar rats. Experimental Gerontology, 84, 49-60. https://doi.org/10.1016/j.exger.2016.08.014

5.Kim, J. Y., Jung, K. J., Choi, J. S., & Chung, H. Y. (2006). Modulation of the age-related nuclear factor-κB (NF-κB) pathway by hesperetin. Aging Cell, 5(5), 401-411.https://doi.org/10.1111/j.1474-9726.2006.00233.x

COGNITIVE & BRAIN HEALTH

1.Aranarochana, A., Kaewngam, S., Anosri, T., Sirichoat, A., Pannangrong, W., Wigmore, P., & Welbat, J. U. (2021). Hesperidin Reduces Memory Impairment Associated with Adult Rat Hippocampal Neurogenesis Triggered by Valproic Acid. Nutrients, 13(12), 4364.https://doi.org/10.3390/nu13124364

2.Moghaddam, A. H., & Zare, M. (2018). Neuroprotective effect of hesperetin and nano-hesperetin on recognition memory impairment and the elevated oxygen stress in rat model of Alzheimer’s disease. Biomedicine & Pharmacotherapy, 97, 1096-1101.https://doi.org/10.1016/j.biopha.2017.11.047

3.Antunes, M. S., Ladd, F. V. L., Ladd, A. A. B. L., Moreira, A. L., Boeira, S. P., & Cattelan Souza, L. (2021). Hesperidin protects against behavioral alterations and loss of dopaminergic neurons in 6-OHDA-lesioned mice: the role of mitochondrial dysfunction and apoptosis. Metabolic Brain Disease, 36(1), 153-167.https://doi.org/10.1007/s11011-020-00618-y

4.Khan, A., Ikram, M., Hahm, J. R., & Kim, M. O. (2020). Antioxidant and anti-inflammatory effects of citrus flavonoid hesperetin: special focus on neurological disorders. Antioxidants, 9(7), 609.https://doi.org/10.3390/antiox9070609

IMMUNE HEALTH

1.Cheng, F. J., Huynh, T. K., Yang, C. S., Hu, D. W., Shen, Y. C., Tu, C. Y., … & Ho, C. Y. (2021). Hesperidin is a potential inhibitor against SARS-CoV-2 infection. Nutrients, 13(8), 2800.https://doi.org/10.3390/nu13082800

2.Miles, E. A., & Calder, P. C. (2021). Effects of citrus fruit juices and their bioactive components on inflammation and immunity: a narrative review. Frontiers in immunology, 12, 2558.https://doi.org/10.3389/fimmu.2021.712608

MICROBIOME BALANCE

1.Estruel-Amades, S., Massot-Cladera, M., Pérez-Cano, F. J., Franch, À., Castell, M., & Camps-Bossacoma, M. (2019). Hesperidin effects on gut microbiota and gut-associated lymphoid tissue in healthy rats. Nutrients, 11(2), 324. https://doi.org/10.3390/nu11020324

2.Unno, T., Hisada, T., & Takahashi, S. (2015). Hesperetin modifies the composition of fecal microbiota and increases cecal levels of short-chain fatty acids in rats. Journal of agricultural and food chemistry, 63(36), 7952-7957. https://doi.org/10.1021/acs.jafc.5b02649

EYE HEALTH

1.Nakazawa, Y., Doki, Y., Sugiyama, Y., Kobayashi, R., Nagai, N., Morisita, N., … & Tamura, H. (2021). Effect of Alpha-Glucosyl-Hesperidin Consumption on Lens Sclerosis and Presbyopia. Cells, 10(2), 382. https://doi.org/10.3390/cells10020382

2.Nakazawa, Y., Oka, M., Bando, M., & Takehana, M. (2015). Hesperetin prevents selenite-induced cataract in rats. Molecular vision, 21, 804. PMID: 26283862

 

HESPERETIN

AND CITRUS BIOFLAVONOIDS

Hesperidin, known as vitamin P in the past, is the major polyphenol in citrus. It was first isolated from orange peel by Leberton in 1828. The name hesperidin is derived from “hesperidium,” referring to thick peel fruits such as oranges, lemons, limes, and tangerines. Hesperidin is absorbed as hesperetin, it is known to have numerous health benefits related to healthy-ageing.